Arrestin Couplings
| Source | Receptor | Ligand | log(Emax/EC50) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Group | Cl | Rec. family |
Uniprot
|
IUPHAR | Name | Phys. / Surr. |
ARRB1 + GRK |
ARRB2 |
ARRB2 + GRK |
|
| Bouvier | A | 5-Hydroxytryptamine | 5HT1A | 5-HT1A | 5-hydroxytryptamine | Phys | 5.1 | 5.0 | 5.4 | |
| Bouvier | A | 5-Hydroxytryptamine | 5HT1B | 5-HT1B | 5-hydroxytryptamine | Phys | 5.7 | 5.4 | 6.0 | |
| Bouvier | A | 5-Hydroxytryptamine | 5HT1D | 5-HT1D | 5-hydroxytryptamine | Phys | 0.0 | 0.0 | 0.0 | |
| Bouvier | A | 5-Hydroxytryptamine | 5HT2A | 5-HT2A | 5-hydroxytryptamine | Phys | 5.9 | 6.0 | 6.4 | |
| Bouvier | A | 5-Hydroxytryptamine | 5HT2B | 5-HT2B | 5-hydroxytryptamine | Phys | 6.6 | 5.6 | 7.1 | |
| Bouvier | A | 5-Hydroxytryptamine | 5HT2C | 5-HT2C | 5-hydroxytryptamine | Phys | 7.7 | 7.4 | 7.8 | |
| Bouvier | A | Acetylcholine (muscarinic) | ACM1 | M1 | acetylcholine | Phys | 0.0 | 3.7 | 3.9 | |
| Bouvier | A | Acetylcholine (muscarinic) | ACM2 | M2 | acetylcholine | Phys | 7.0 | 5.3 | 7.2 | |
| Bouvier | A | Dopamine | DRD2 | D2 | dopamine | Phys | 5.7 | 5.2 | 6.0 | |
| Bouvier | A | Acetylcholine (muscarinic) | ACM3 | M3 | acetylcholine | Phys | 4.4 | 3.8 | 4.7 | |
| Bouvier | A | Acetylcholine (muscarinic) | ACM4 | M4 | acetylcholine | Phys | 5.9 | 4.9 | 6.4 | |
| Bouvier | A | Adrenoceptors | ADA1A | α1A-adrenoceptor | noradrenaline | Phys | 0.0 | 0.0 | 4.8 | |
| Bouvier | A | Adrenoceptors | ADA2A | α2A-adrenoceptor | noradrenaline | Phys | 5.6 | 5.1 | 5.7 | |
| Bouvier | A | Adrenoceptors | ADA2B | α2B-adrenoceptor | noradrenaline | Phys | 5.6 | 5.1 | 5.9 | |
| Bouvier | A | Adrenoceptors | ADA2C | α2C-adrenoceptor | noradrenaline | Phys | 4.8 | 4.4 | 6.1 | |
| Bouvier | A | Adrenoceptors | ADRB1 | β1-adrenoceptor | noradrenaline | Phys | 5.6 | 5.5 | 5.8 | |
| Bouvier | A | Adrenoceptors | ADRB2 | β2-adrenoceptor | noradrenaline | Phys | 3.5 | 4.0 | 4.8 | |
| Bouvier | A | Dopamine | DRD1 | D1 | dopamine | Phys | 4.7 | 4.6 | 5.0 | |
| Bouvier | A | Dopamine | DRD5 | D5 | dopamine | Phys | 5.4 | 5.6 | 5.9 | |
| Bouvier | A | Histamine | HRH1 | H1 | histamine | Phys | 3.4 | 4.1 | 5.1 | |
| Bouvier | A | Histamine | HRH2 | H2 | histamine | Phys | 4.0 | 0.0 | 4.4 | |
| Bouvier | A | Angiotensin | AGTR1 | AT1 | angiotensin II | Phys | 7.5 | 7.3 | 7.7 | |
| Bouvier | A | Apelin | APJ | apelin | [Pyr1]apelin-13 | Phys | 7.7 | 6.7 | 7.7 | |
| Bouvier | A | Bradykinin | BKRB1 | B1 | kallidin | Phys | 0.0 | 0.0 | 0.0 | |
| Bouvier | A | Bradykinin | BKRB2 | B2 | kallidin | Phys | 8.4 | 8.0 | 8.1 | |
| Bouvier | A | Cholecystokinin | CCKAR | CCK1 | CCK-8 | Phys | 8.0 | 7.4 | 8.4 | |
| Bouvier | A | Complement peptide | C5AR1 | C5a1 | C5a | Phys | 7.8 | 7.3 | 7.6 | |
| Bouvier | A | Endothelin | EDNRA | ETA | endothelin-1 | Phys | 7.5 | 7.7 | 8.1 | |
| Bouvier | A | Ghrelin | GHSR | ghrelin | ghrelin | Phys | 6.6 | 7.6 | 7.3 | |
| Bouvier | A | Gonadotrophin-releasing hormone | GNRHR | GnRH1 | GnRH I | Phys | 0.0 | 0.0 | 0.0 | |
| Bouvier | A | Melanocortin | MC3R | MC3 | γ-MSH | Phys | 7.0 | 7.9 | 8.1 | |
| Bouvier | A | Melanocortin | MC4R | MC4 | α-MSH | Phys | 0.0 | 5.2 | 5.9 | |
| Bouvier | A | Neuropeptide FF/neuropeptide AF | NPFF1 | NPFF1 | RFRP-3 | Phys | 7.0 | 6.2 | 7.1 | |
| Bouvier | A | Neuropeptide FF/neuropeptide AF | NPFF2 | NPFF2 | neuropeptide FF | Phys | 0.0 | 0.0 | 6.1 | |
| Bouvier | A | Neuropeptide Y | NPY1R | Y1 | neuropeptide Y | Phys | 6.4 | 0.0 | 7.0 | |
| Bouvier | A | Neuropeptide Y | NPY5R | Y5 | neuropeptide Y | Phys | 0.0 | 0.0 | 0.0 | |
| Bouvier | A | Opioid | OPRD | δ | SNC80 | Surr | 6.5 | 6.1 | 7.0 | |
| Bouvier | A | Opioid | OPRK | κ | dynorphin A | Phys | 7.2 | 7.2 | 7.3 | |
| Bouvier | A | Opioid | OPRM | μ | DAMGO | Surr | 6.6 | 5.2 | 7.0 | |
| Bouvier | A | Opioid | OPRX | NOP | nociceptin/orphanin FQ | Phys | 6.9 | 7.0 | 7.6 | |
| Bouvier | A | Orexin | OX2R | OX2 | orexin-A | Phys | 7.9 | 7.7 | 8.0 | |
| Bouvier | A | Proteinase-activated | PAR1 | PAR1 | TFLLR-NH2 | Phys | 4.3 | 4.3 | 4.4 | |
| Bouvier | A | Proteinase-activated | PAR2 | PAR2 | PAR2 peptide | Phys | 4.1 | 4.0 | 4.0 | |
| Bouvier | A | Somatostatin | SSR2 | SST2 | SRIF-14 | Phys | 8.8 | 8.1 | 8.7 | |
| Bouvier | A | A orphans | GPR4 | GPR4 | pH (proton) | Phys | 5.8 | 5.8 | 0.0 | |
| Bouvier | A | Vasopressin and oxytocin | V1AR | V1A | vasopressin | Phys | 7.2 | 7.2 | 7.3 | |
| Bouvier | A | Vasopressin and oxytocin | V2R | V2 | vasopressin | Phys | 6.7 | 6.9 | 6.9 | |
| Bouvier | A | Vasopressin and oxytocin | OXYR | OT | oxytocin | Phys | 6.7 | 7.0 | 7.5 | |
| Bouvier | A | Chemokine | CCR5 | CCR5 | CCL3 | Phys | 7.7 | 6.6 | 7.9 | |
| Bouvier | A | Chemokine | CCR6 | CCR6 | CCL2 | Phys | 6.3 | 6.1 | 6.3 | |
| Bouvier | A | Chemokine | CXCR2 | CXCR2 | CXCL8 | Phys | 8.3 | 7.3 | 7.5 | |
| Bouvier | A | Chemokine | CXCR4 | CXCR4 | CXCL12α | Phys | 6.4 | 4.8 | 5.8 | |
| Bouvier | A | Chemokine | CXCR5 | CXCR5 | CXCL13 | Phys | 6.5 | 6.2 | 6.6 | |
| Bouvier | A | Free fatty acid | FFAR2 | FFA2 | propanoic acid | Phys | 0.0 | 0.0 | 0.0 | |
| Bouvier | A | Free fatty acid | FFAR3 | FFA3 | propanoic acid | Phys | 0.0 | 0.0 | 0.0 | |
| Bouvier | A | Free fatty acid | FFAR4 | FFA4 | α-linolenic acid | Phys | 4.3 | 4.5 | 4.4 | |
| Bouvier | A | Leukotriene | LT4R1 | BLT1 | LTB4 | Phys | 6.7 | 7.3 | 7.6 | |
| Bouvier | A | Leukotriene | LT4R2 | BLT2 | LTB4 | Phys | 0.0 | 5.5 | 5.3 | |
| Bouvier | A | Leukotriene | CLTR1 | CysLT1 | LTB4 | Phys | 5.6 | 5.6 | 5.8 | |
| Bouvier | A | Leukotriene | CLTR2 | CysLT2 | LTB4 | Phys | 5.5 | 2.5 | 6.1 | |
| Bouvier | A | Lysophospholipid (LPA) | LPAR1 | LPA1 | 2-oleoyl-LPA | Phys | 6.5 | 5.7 | 6.4 | |
| Bouvier | A | Lysophospholipid (LPA) | LPAR2 | LPA2 | 2-oleoyl-LPA | Phys | 6.2 | 5.8 | 6.6 | |
| Bouvier | A | Lysophospholipid (S1P) | S1PR1 | S1P1 | sphingosine 1-phosphate | Phys | 6.5 | 5.7 | 6.7 | |
| Bouvier | A | Cannabinoid | CNR1 | CB1 | WIN55212-2 | Surr | 0.0 | 4.2 | 5.1 | |
| Bouvier | A | Cannabinoid | CNR2 | CB2 | WIN55212-2 | Surr | 7.2 | 6.8 | 7.2 | |
| Bouvier | A | Prostanoid | PE2R1 | EP1 | PGE2 | Phys | 0.0 | 5.5 | 0.0 | |
| Bouvier | A | Prostanoid | PE2R2 | EP2 | PGE2 | Phys | 5.1 | 5.6 | 5.5 | |
| Bouvier | A | Prostanoid | PE2R3 | EP3 | PGE2 | Phys | 0.0 | 0.0 | 0.0 | |
| Bouvier | A | Prostanoid | PE2R4 | EP4 | PGE2 | Phys | 7.8 | 7.7 | 7.9 | |
| Bouvier | A | Prostanoid | PF2R | FP | PGD2 | Phys | 0.0 | 0.0 | 0.0 | |
| Bouvier | A | Melatonin | MTR1A | MT1 | melatonin | Phys | 7.4 | 7.7 | 7.5 | |
| Bouvier | A | Melatonin | MTR1B | MT2 | melatonin | Phys | 5.6 | 0.0 | 6.3 | |
| Bouvier | A | Adenosine | AA1R | A1 | adenosine | Phys | 0.0 | 4.6 | 4.7 | |
| Bouvier | A | Adenosine | AA2AR | A2A | adenosine | Phys | 0.0 | 0.0 | 0.0 | |
| Bouvier | A | Adenosine | AA2BR | A2B | adenosine | Phys | 0.0 | 0.0 | 0.0 | |
| Bouvier | A | Adenosine | AA3R | A3 | adenosine | Phys | 0.0 | 0.0 | 0.0 | |
| Bouvier | A | P2Y | P2RY2 | P2Y2 | UTP | Phys | 4.0 | 4.1 | 3.9 | |
| Bouvier | A | Bile acid | GPBAR | GPBA | lithocholic acid | Phys | 0.0 | 0.0 | 0.0 | |
| Bouvier | A | Hydroxycarboxylic acid | HCAR2 | HCA2 | nicotinic acid | Phys | 4.6 | 4.6 | 5.3 | |
| Bouvier | A | Hydroxycarboxylic acid | HCAR3 | HCA3 | 3-hydroxyoctanoic acid | Phys | 2.8 | 2.1 | 2.7 | |
| Bouvier | A | A orphans | GPR39 | GPR39 | Zn2+ | Phys | 0.0 | 2.3 | 2.2 | |
| Bouvier | A | A orphans | PSYR | GPR65 | pH (proton) | Phys | 4.3 | 4.7 | 0.0 | |
| Bouvier | A | A orphans | OGR1 | GPR68 | pH (proton) | Phys | 4.7 | 4.5 | 4.8 | |
| Bouvier | A | A orphans | GPR84 | GPR84 | undecanoic acid | Phys | 0.0 | 0.0 | 1.0 | |
| Bouvier | A | A orphans | GP183 | GPR183 | 7α,25-dihydroxycholesterol | Phys | 8.5 | 7.5 | 8.1 | |
| Bouvier | B1 | Calcitonin | CALCR | CT | Human Calcitonin (hCT) | Phys | 0.0 | 0.0 | 7.0 | |
| Bouvier | B1 | Corticotropin-releasing factor | CRFR1 | CRF1 | urocortin 2 | Phys | 6.4 | 5.8 | 6.0 | |
| Bouvier | B1 | Corticotropin-releasing factor | CRFR2 | CRF2 | urocortin 2 | Phys | 7.8 | 7.5 | 7.8 | |
| Bouvier | B1 | Glucagon | GIPR | GIP | gastric inhibitory polypeptide | Phys | 5.7 | 6.4 | 7.0 | |
| Bouvier | B1 | Glucagon | GLP1R | GLP-1 | glucagon-like peptide 1-(7-37) | Phys | 7.6 | 7.5 | 7.9 | |
| Bouvier | B1 | Glucagon | GLP2R | GLP-2 | glucagon-like peptide 2 | Phys | 8.1 | 7.1 | 8.0 | |
| Bouvier | B1 | Glucagon | GLR | glucagon | glucagon | Phys | 7.0 | 7.0 | 7.7 | |
| Bouvier | B1 | Parathyroid hormone | PTH1R | PTH1 | teriparatide | Phys | 8.7 | 8.0 | 8.5 | |
| Bouvier | B1 | VIP and PACAP | VIPR1 | VPAC1 | VIP | Phys | 8.8 | 8.5 | 8.8 | |
| Bouvier | C | Metabotropic glutamate | GRM2 | mGlu2 | L-glutamic acid | Phys | 0.0 | 0.0 | 0.0 | |
| Bouvier | C | Metabotropic glutamate | GRM4 | mGlu4 | L-glutamic acid | Phys | 0.0 | 0.0 | 0.0 | |
| Bouvier | C | Metabotropic glutamate | GRM5 | mGlu5 | L-glutamic acid | Phys | 0.0 | 3.1 | 0.0 | |
| Bouvier | C | Metabotropic glutamate | GRM6 | mGlu6 | L-glutamic acid | Phys | 0.0 | 0.0 | 0.0 | |
| Bouvier | C | Metabotropic glutamate | GRM8 | mGlu8 | L-glutamic acid | Phys | 0.0 | 0.0 | 0.0 | |